Mentor Karemani, Basri Lenjani
Introduction: The stomach is a muscular bag that performs important functions such as: receiving food coming from the esophagus, processing it, separating albumins and fats, and sending processed food to the intestines.
Diseases: one of the most problematic diseases is gastric ulcer, by which we mean the benign ulceration of the wall of the digestive tract, which includes the mucosa, submucosa, and muscular layer. Ulcer differs from erosion as it is localized only in the mucosa.
Treatment: It is medicinal and surgical, in the first group, among other drugs, H2-blockers are included. These include cimetidine, ranitidine, nizatidine, and roxatidine.
Action: All H2 antihistamines are orally active. With the competitive blocking of H2-receptors, the basal secretion of HCl decreases by 90%. They inhibit the secretion of HCl from the stomach, almost without affecting the formation of gastric mucus and pepsin.
Statistics: The results obtained on 2.11.2010 included 200 patients with gastroduodenal ulcers. 60% were women, aged over 40 years who dominated, the rest 40% were men, also here the age over 40 years dominated.
Aim of the paper: General theoretical aspects related to gastric ulcers in the human body and to analyze H2- blockers as drugs, and how they affect gastric ulcers.