Estradiol Synthesis and Metabolism and Risk of Ovarian Cancer in Older Women Taking Prescribed or Plant-derived Estrogen Supplementation

Linda S M Gulliver

Estradiol, the most potent of the biological estrogens, is implicated in the genesis of ovarian epithelial cancer, a heterogeneous cancer affecting mainly older women. The postm..Ver más»

A Novel Validation Strategy for Next Generation Sequencing Mutation Profiling in FFPE Tissues

Ken CN Chang, Gladys Arreaza, John Kang, Maureen Maguire, Ping Qiu and Matthew J Marton

Abstract

We previously developed a “concordance calculator” to quantify reproducibility of multi-variant calls among next generation sequencing (NGS) sampl..Ver más»

Effect of Exercise on Pancreatic Islets in Zucker Diabetic Fatty Rats

Sonia Rawal, Han-Hung Huang, Lesya Novikova, Tyler Hamedi, Irina V Smirnova and Lisa Stehno-Bittel

Exercise and physical activity improve the glycemic control in people with type 2 diabetes (T2D). It is known that activity improves muscle utilization of glucose, and that exer..Ver más»

A Double Blind, Randomised, Four Arm Clinical Study to Evaluate the Safety, Efficacy and Tolerability of Collagen Peptide as a Nutraceutical Therapy in the Management of Type II Diabetes Mellitus

Sheena Devasia, Suresh Kumar, Stephena PS, Naoki Inoue, Fumihito Sugihara, Seiko Koizumi, Aya Matsushita, Sriraam VT

Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute an innovative class of oral agents for the treatment of Type 2 Diabetes Mellitus (T2DM). DPP-4 inhibitors increase glucagon-..Ver más»

Acute Toxicity (LD₅₀) Studies Using Swiss Albino Mice and Brine Shrimp Lethality (LC₅₀ and LC₉₀) Determination of the Ethanol Extract of Stem Bark of Echinaceae angustifolia DC.

Abdu Zakari and Dimas Kubmarawa

The ethanol extract of Echinaceae angustifolia DC was tested for acute toxicity (LD₅₀) using Swiss Albino Mice and was screened for Brine Sh..Ver más»

Structural Variation Detection from Next Generation Sequencing

Ye K, Hall G, Ning Z

Structural variations (SVs) are the genetic variations in the structure of chromosome with different types of rearrangements. They comprise millions of nucleotides of heterogene..Ver más»