Dr. Sanjeev Kumar*, Dr. Kumari Shachi
From time immemorial therapeutic potential of Curcuma longa linn is known. In present study an effort has been made to assess the hypoglycemic, anticholesterolmic, anti-ureatic, anti-creatinic and Oral Glucose Tolerance Test (OGTT) activity of Curcuma longa juice in alloxan monohydrate induced experimental animal model. Rats were acclimatized for 7 days in lab temperature. All animals were given standard water and pellet diet. Diabetes was induced in rats with the help of alloxan monohydrate. After alloxan monohydrate injection rats were separated and treatment started with Curcuma longa juice and insulin. A marked rise in fasting blood glucose, serum cholesterol, serum creatinine, serum urea level were observed in diabetic control rats when compared to normal control rats. Anti-hyperglycemic, anticholesterolmic, anti-creatinic, anti-ureatic activity observed in Curcuma longa fresh root juice administered rats on 10th, 20th, 30th and 40th days post treatment. Anti-hyperglycemic, anti-cholesterolmic, anti-ureatic, anti-cratinic activity was found almost similar effective like insulin treatment group. It is hope that present investigation will be helpful in establishing a scientific basis for anti-diabetic, anti-cholesterolmic, anti-creatinic, anti-ureatic effects in experimental animal model. The results are statistically significant.