May Anne C Plarisan* and Jennifer A Macaraig
This is an open label randomized control study comparing 2 protocols of mannitol administration in laparoscopic donor nephrectomy: upon adequate exposure of kidney hilum and 15 minutes prior to cross clamping. We observed its effects on the intraoperative mean arterial pressure (MAP) of donor patients, daily urine output, creatinine clearance and the length of hospital stay of graft recipients.
Forty-two pairs of subjects were enrolled after written consent was obtained. Computer-generated randomization assigned the allograft donor-recipient to 21 pairs per treatment arm. Group A was administered mannitol 0.25 g/kg before skin incision and 0.5 g/kg once the kidney hilum was adequately exposed. Group B received mannitol 0.25g/ kg before skin incision and 0.5g/kg 15 minutes prior to cross clamping. All 42 pairs successfully completed the study.
Mannitol, when administered 15 minutes prior to cross clamping, significantly increased urine output in day 1 posttransplantation. The creatinine clearance and length of hospital stay were independent of the timing of mannitol administration.